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Investigator(s):
Giuseppe Giaccone, M.D., Ph.D. Principal Investigator Phone: 301-496-4916 Fax: 301-402-0172 giacconeg@mail.nih.gov
Referral Contact(s):
Corrine Keen, R.N., M.S., O.C.N. Research Nurse Phone: 301-496-3778 ckeen@mail.nih.gov	Arlene Berman, R.N., M.S., O.C.N. Research Nurse Phone: 301-435-5609 arleneb@mail.nih.gov

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Primary Eligibility:

• ≥ 18 years of age
• Diagnosis of primary lung carcinoma
• Non-small cell lung cancer
• Stages I to IV
• May receive any treatment (surgical resection, chemotherapy, radiation, molecularly targeted therapy)
• Small cell lung cancer
• Limited or extensive stage
• May receive any treatment (surgical resection, chemotherapy, radiation, molecular targeted therapy)
• ECOG 0–3
• Current diagnosis of or a prior history of other cancers allowed
• Normal organ function not required

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Study Outline:

• Single 7-mL sample of venous blood will be obtained for isolation of DNA
• Polymorphisms in the following genes will be analyzed by the Clinical Pharmacology Program: ABCB1, ABCG2, COMT, CYP17, CYP19, CYP1B1, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2J2, CYP3A4, CYP3A5, DPYD, EPHX2, ERalpha, ERbeta, ERCC1, ERCC2, GSTP1, HIF1A, MPO, MTHFR, NQO1, p53, PPARD, SLCO1B3, TYMS, UGT1A1, VEGF, VEGFR, EGFR, SLC28A1, CDA, XRCC1, OCT1, and OCT2
• Patients will be followed at the medical oncology clinic at the Washington, D.C., VA Hospital or at the National Cancer Institute but are only required to have one visit to the clinic in person. Additional information may be collected by phone call follow up
• Age, gender, race/ethnicity, smoking history, histology, stage, treatment(s) received, response, toxicity, time to disease progression, time to death will be recorded in a confidential database

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Additional Information:

• This trial will be conducted at the NIH Clinical Center in Bethesda, MD. It is open to patients who meet the eligibility requirements, regardless of where they live in the United States.
• There is no charge for medical care received at NIH Clinical Center.
• FAQs about this study - provides information for patients about the trial such as frequency and duration of visits, costs, how to enroll, treatment plan.
• PDQ (Physicians Data Query) - provides additional details about this study for health care providers.

Reviewed: 9/9/09
Updated: 9/16/09