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Investigator(s):
Itzhak Avital, M.D. Principal Investigator Phone: 301-402-0083 Fax: 301-496-0734 avitali@mail.nih.gov
Referral Contact(s):
Melissa Walker, R.N., B.S.N. Research Nurse Phone: 301-402-9537 Fax: 301-594-5356 walkerme@mail.nih.gov

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Primary Eligibility:

• Radiographically, biochemically, and/or histologically/cytologically confirmed solid tumor, including any of the following:
• Hepatobiliary cancer, pancreatic cancer, colorectal cancer, gastric cancer, breast cancer, adrenal cancer, mesothelioma, anal cancer, female reproductive tract cancer, melanoma, or sarcoma
• Rare solid tumors, including, but not limited to, small intestine cancer, vaginal cancer, vulvar cancer, carcinoid, skin cancer, pediatric cancer, Kaposi sarcoma, or cancers of unknown origin

[Note: Children between the ages of 16 and 18 years with gastrointestinal cancers, melanoma, or sarcoma may participate in this trial as part of the rare cancers group]

• Patients with premalignant conditions who are scheduled to undergo surgery or biopsy as part of their diagnostic evaluation are eligible
• Primary or metastatic disease for which surgery or biopsy are considered acceptable
• Not planning to undergo surgery or biopsy for the sole purpose of tissue procurement
• Able to provide adequate tumor tissue samples
• Hormone receptor status not specified
• Concurrent participation in other NIH protocols for treatment of the cancer is allowed
• Menopausal status not specified
• ECOG performance status 0–2
• Laboratory and physical examination parameters normal (before undergoing biopsy or surgery)

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Study Outline:

• Patients undergo tissue (normal and tumor tissue), bone marrow, and/or peritoneal washing sample collection during surgery or biopsy
• Patients also undergo blood sample collection prior to surgery or biopsy and then periodically for up to 5 years
• After surgery or biopsy, patients are followed periodically for up to 5 years

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Additional Information:

• This trial will be conducted at the NIH Clinical Center in Bethesda, MD. It is open to patients who meet the eligibility requirements, regardless of where they live in the United States.
• There is no charge for medical care received at NIH Clinical Center.
• FAQs about this study - provides information for patients about the trial such as frequency and duration of visits, costs, how to enroll, treatment plan.
• PDQ (Physicians Data Query) - provides additional details about this study for health care providers.

Reviewed: 
Updated: 6/22/09