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Investigator(s):
David S. Schrump, M.D. Principal Investigator Phone: 301-496-2128 Fax: 301-451-6934 David_Schrump@nih.gov
Referral Contact(s):
Tricia Kunst, R.N. Research Nurse Phone: 301-451-1233 Fax: 301-451-6933 tricia_kunst@nih.gov	Ana Hancox, R.N. Research Nurse Phone: 301-451-1233 Fax: 301-451-6933 ana_hancox@nih.gov

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Primary Eligibility:

• Patients with radiographic evidence of, or histologically/cytologically proven, lung cancers or esophageal cancers, malignant pleural mesotheliomas, mediastinal or chest wall neoplasms, or pulmonary metastases from cancers of non-thoracic origin, are eligible for evaluation
• Patients with concomitant intracranial metastases, which are potentially treatable by surgery and/or radiation therapy, are eligible for study
• Patients must have coagulation parameters within acceptable limits by standard of practice guidelines prior to biopsy

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Study Outline:

• Participants undergo standard tests for evaluating the stage of their disease and for determining their eligibility for participation in an NCI treatment study
• Participants undergo bronchoscopy and bronchoalveolar lavage, standard tumor assessment procedures
• Participants undergo tumor biopsy
• Treatment options are discussed after the patient’s cancer is staged
• Patients who are eligible for a treatment study at NCI are offered participation in the study
• Patients for whom standard surgery, radiation, or chemotherapy is more appropriate may receive treatment at NCI or with their own physician
• Patients who receive treatment at NCI return for follow-up examinations 4 weeks after discharge and then every 2-4 months depending on the nature of their cancer

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Additional Information:

• This trial will be conducted at the NIH Clinical Center in Bethesda, MD. It is open to patients who meet the eligibility requirements, regardless of where they live in the United States.
• There is no charge for medical care received at NIH Clinical Center.
• FAQs about this study - provides information for patients about the trial such as frequency and duration of visits, costs, how to enroll, treatment plan.
• PDQ (Physicians Data Query) - provides additional details about this study for health care providers.

Reviewed: 9/3/09
Updated: 11/14/08